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HDM-2 membrane overexpression has been confirmed across a wide range of cancer types in pre-clinical literature, including breast cancer, pancreatic cancer, ovarian cancer, lung cancer, colon cancer, cervical cancer, melanoma, osteosarcoma, and several haematological malignancies

In the tail suspension test (TST), the animals were hung on a bar for 6 minutes, and the immobility period, determined as the time displaying no motion, was recorded during the last 4 minutes

FOXP3 expression diversifies the metabolic capacity and enhances the efficacy of CD8 T cells in adoptive immunotherapy of melanoma

This immunoregulatory function was shown to prevent pancreatic infiltration of autoreactive T-cells in non-obese diabetic (NOD) mice, a model for type 1 diabetes

Usui et al., 2010)