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This is why oral administration is most defensible for GI-specific indications

Most researchers notice gradual return toward baseline over weeks to months after stopping

It also explains why the same person might be dosed differently at two points in time: as tolerance, response, and objectives shift, so can the appropriate amount

Gomez EA, Colas RA, Souza PR, Hands R, Lewis MJ, Bessant C, Pitzalis C, Dalli J

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Symptoms can include fatigue, weakness, numbness or tingling in the hands and feet, difficulty walking, memory issues, and anemia