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Talanta 174:539547 Urig S, Becker K (2006) On the potential of thioredoxin reductase inhibitors for cancer therapy

The modification provides practical half-life without going to the dramatically extended timeframe of CJC-1295 with DAC

Modelling of the point mutations within the DHFR crystal structure suggested that E173D contributes to a higher conformational flexibility and increases the exposure of Lys side chains on the surface under elevated temperatures

10.1097/MCO.0b013e3283659a51 65 GrochowskiC.LitakJ.KamieniakP.MaciejewskiR

Fariello RM, Del Giudice PT, Spaine DM, Fraietta R, Bertolla RP, Cedenho AP

[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy