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B.LiJ.et al (2024)

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Among chronic DILI, persistent DILI is defined by the International Expert Committee in 2011 as abnormalities in liver markers persisting for more than 3 months in the hepatocellular injury type and more than 6 months in the cholestatic injury type after discontinuation of the causative drug, whereas chronic DILI is defined as abnormalities in liver markers persisting for more than 12 months regardless of the phenotype of DILI. 24 Chronic DILI may cause drug-induced AIH (DI-AIH), nonalcoholic steatohepatitis-like conditions, vanishing bile duct syndrome, nodular regenerative hyperplasia, peliosis hepatis, and liver cirrhosis (Table 1)

[14] As a second method, there is a biological method using microorganisms or enzymes