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255 Alternatively, Bmal1 loss may hyperactivate the mTORC1 pathway in OA cartilage, driving cartilage degradation and chondrocyte apoptosis

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Cardiac-specific overexpression of AC8 in 3-month-old transgenic mice alters several pathways, resulting in elevated AC activity and cAMP-induced cardiac workload until up to 1 year of age, without excess mortality or onset of heart failure (Tarasov et al., 2022