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NDELA, classified as carcinogen (IARC 2000), mediated a concentration-dependent increase in mean TI in both PHH, PRH, and HepG2 cells with rat and hamster S9-mix with mfcs of 5.0, 2.2, 2.4, and 2.2, respectively (Table 4)

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These pro- and anti-angiogenic proteins are stored in different compartments of the -granules and are selectively released upon different stimuli [68, 69]