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The appeal stems from a fundamental biological advantage

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SEs, or super enhancers, defined as significant clusters of transcriptional enhancers essential in facilitating tumorigenesis [25]

The negative results of the latter study may, at least partly, be due to the large heterogeneity of causes of AKI (trauma, hypertension, surgery, drugs or sepsis) and/or the delayed initiation of rhIGF-1 treatment, i.e., after established AKI