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doi: 10.1172/JCI46110 20

For instance, progenitor-exhausted T cells (Texprog) have been found to highly express proliferation-related genes such as Ki67 and CCNA2, whereas terminally exhausted T cells (Teterm) exhibit elevated expression of inhibitory receptor genes like PD-1 and TIM-3

doi:10.1096/fasebj.9.15.8529833 ^ a b Britton G., Liaaen-Jensen S., Pfander H

Globally, the per capita alcohol consumption increased from 5.5 liters in 2005 to 6.4 liters in 2016 and is estimated to further increase to 7.6 liters by 2030 [2]

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In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]