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Quite a few mechanisms have been linked to the deregulation of this pathway, and these include p53 mutation, HMG-CoAR mutation, SREBP cleavage, PKB/Akt activation, decreased AMPK activation and activation of transcription factors such as SREBP and hypoxia-inducible factors (HIF-1)

Galzigna, L., De Iuliis, A., & Zanatta, L

If it can lighten the skin, people reason, surely it can lighten the iris

We selected for further analysis any gene candidates that appeared in the first tercile of either scoring method (2a or 2b)

Enhancer decommissioning by LSD1 during embryonic stem cell differentiation

Long-term vitamin B12 deficiency may cause permanent nerve damage if untreated