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10.1016/S0021-9258(18)61530-3 18

Blood work will need to be run periodically during treatment to monitor the drugs effectiveness, as well as kidney and liver function

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The majority of renoprotective claims derive from rodent models (primarily db/db mice, streptozotocin-induced diabetes, or high-fat diet models), which exhibit fundamental differences from human DKD in gut microbiota composition, metabolic kinetics, and disease progression timelines

It can result from gut damage, poor motility, glyphosate exposure, or FODMAP fermentation in grains

They found that rats pretreated with tocotrienol showed GSH/GSSG ratios that did not differ significantly from non-irradiated controls, suggesting overall reduction in oxidative stress which may lead to the protective effects against mitochondrial damage [52]