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We use both topical anesthetics and a targeted local nerve block

This is one reason why proper storage and shipping practices are important parts of quality control

Addition of a methyl group (-CH3) to the 3 position changes morphine to codeine, masks the OH group and confers greater fat-solubility to the molecule allowing it to be more preferentially absorbed

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As for its fatty acid profile, it contains 48-59% barrier-repairing linoleic acid, 17-30% nourishing oleic acid and also some (4.5-11%) potentially anti-inflammatory linolenic acid