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In mitochondria, SIRT3 is a nutrient sensor, serving to regulate and stabilize mitochondria, and thus maintain homeostasis of the entire cell

Since a relationship has been demonstrated between oxidative stress and systemic inflammation (82, 83), peripheral oxidative stress and inflammation in ASD patients cannot be ignored

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Moreover, FUS is glutathionylated at the Cys447 residue on the ZnF domain 148

Zhang J, Wu C, Zhang J, Jujimoto J, Song XM, Mao X, Sun H, Seth S, Thornton R, Coyle M, Little L, Gumbs C, Behrens C, Chow C, Sulman E, Rao G, Swisher S , Wistuba I, Heymach J, Futreal A, Gomez D

The reaction catalyzed by GPAT is the regulatory enzyme of the pathway