l carnitine congestive heart failure is a friend in HFpEF and foe in HFrEF The Role of L-Carnitine in

Gene expression and enrichment analyses revealed that, compared with PHHs, the matching h-HepOrgs exhibited a proliferative signature that was maintained until late passages (greater than passage 10) and resembled regenerating tissue after hepatectomy (Extended Data Fig

doi: 10.2337/diabetes.55.03.06.db05-0453 138 RajkhowaMBrettSCuthbertsonDJLipinaCRuiz-AlcarazAJThomasGEet al

Developing therapies for HFpEF

16 Iron deficiency has been associated with RLS since its early description by Ekbom, 17 and relates to brain iron deficiency rather than serum iron deficiency, which only occurs in 2544% of RLS patients

to investigate the melatonin ability to regulate the antioxidant defense system and evaluate its nephroprotective role in higher doses of methotrexate.97 In addition to previously studied biochemical parameter, they found that methotrexate severely reduced the cellular content of antioxidant enzymes such as SOD, CAT, GPx, GRd and GST

conversely, with sensitivity constrained at 90%, specificity was 57.8%