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Overall, our transcriptomic data-based analysis highlights the partially overlapping nature of EMT with molecular attributes of de-differentiation and metabolism during drug treatment in melanoma

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In comparison, primary Kupffer cells are less frequently available, show significant batch-to-batch variability and are often contaminated with other non-parenchymal cell fractions 71

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Tirzepatide currently leads with higher weight loss percentages and extensive clinical data, while mazdutide shows promise as a dual GLP-1 and glucagon agonist with strong phase II results