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Moreover, alterations in signalling through these pathways leads to a diverse number of diseases including many cancers, neurodevelopmental disorders and metabolic syndromes, highlighting the critical importance of understanding the precise regulation of these pathways and their interconnectivity

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In addition, inflammatory cells release a large amount of oxidants and cytokines (Piano and Angeli, 2021), such as TNF which imitates the effect of uncouplers in mitochondria, contributing to the decrease in ATP production (Kastl et al., 2014