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Data Animal Data In rats, administered 20 mg/kg/day amlodipine plus 320 mg/kg/day valsartan, treatment-related maternal and fetal effects (developmental delays and alterations noted in the presence of significant maternal toxicity) were noted with the high dose combination

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Notably, vinegar frying significantly reduces the content of these toxic constituents, thereby attenuating toxicity [151, 152]

2 Pathological mechanisms of heat stress-induced sperm damage 2.1 Spermatogenic microenvironment disruption and resultant failure Spermatogenesis in mammals constitutes a highly intricate and precisely orchestrated process of cellular differentiation, the fidelity of which depends upon the stability of the testicular spermatogenic microenvironment

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