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NNMT inhibition increases NAD+ availability, which is known to support mitochondrial function, reduce fibrosis, and lower inflammation

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In neurons derived from two independent AD iPSC lines, more A42 was produced than in normal control iPSC-derived neurons (Fig

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doi: 10.1097/MED.0000000000000425 21 PaparoSRFerrariSMPatrizioAEliaGRagusaFBotriniCet al