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Due to the comparative small size of the rats and large size of the defects, these defects would fairly mimic large fistulas in patients that would hardly heal spontaneously

All four commercially available botulinum toxin type A products mentioned in the study cited by the commenter are supplied in single-dose vials and instruct users to discard any unused remaining solution

FIRST AID IF SWALLOWED, rinse mouth

The problem is that most resources either dismiss side effects entirely or exaggerate them into something terrifying

Nature 380:435439 Henry TD, Annex BH, McKendall GR, Azrin MA, Lopez JJ, Giordano FJ, Shah PK, Willerson JT, Benza RL, Berman DS et al (2003) The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis