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Regulatory agencies such as the FDA and EMA classify live modified microorganisms as higher-risk biological products, necessitating extensive preclinical safety evaluation, including assessment of genetic stability, exclusion of horizontal gene transfer, immunogenicity testing, and environmental biosafety analyses (Rouanet et al., 2020

Transcriptomic data suggested the involvement of MAPK and heat shock protein-necroptotic pathways in ZEA toxicity and the response to scutellarin (Yi et al., 2022)

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