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AOD 9604 was initially studied and used as an anti-obesity drug

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However, overnight exposure may reduce potency

AOD-9604 differs from other metabolic peptides in its selective mechanism and side effect profile

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Although peripheral and central enterostatin administration decreases dietary fat intake in animals (while enterostatin-receptor antagonists did the opposite) (186), its administration to humans has shown no effects on food intake, appetite, energy expenditure, or body weight (187)