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Two decades later, Kovalzon and Strekalova (2006) [6] were equally direct, calling DSIP a still unresolved riddle and noting that the connection between the peptide and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. That framing has not materially changed in the literature since

Blood samples were collected at 2wpD (tp0), 7wpD (tp1) and 13wpD (tp2), with the latter two being taken 4 and 10 weeks post anti-PD1 (wpP), respectively ( Figure 1 )

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Using a 2 mL syringe, samples were taken periodically for analysis of ascorbate, which would be present principally as the monoanion