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A 2a receptor plays an anti-inflammatory role in specific cells and various inflammation models

Xie S, Liu H, Zhu S, et al

PLoS Pathog 10 , e1004566 (2014)

A role for autoantibodies in enhancement of pro-inflammatory cytokine responses to a self-antigen, thyroid peroxidase

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Existing studies are mostly preliminary, involve small cohorts, and lack long-term randomized controlled trials, which limits the strength of current conclusions