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Among them, cysteine S-nitrosylation and tyrosine nitration are prominent indicators of nitrosative stress, reflecting a direct interplay between redox control and protein function

This lack of efficacy may be attributed to the low plasma and sputum concentrations of NTZ and the high plasma protein binding of tizoxanide, the active metabolite of NTZ [80], highlighting the need for further pharmacokinetic optimization and clinical research to better understand its potential role in TB treatment

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2021;100: e26875

The release of apoptogenic proteins results in the activation of caspase 9 (initiator caspase), which in turn activates the executioner caspases 3, 6, and 7, resulting in the disassembly of the cell (132)

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