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Samples were centrifuged at 4 C for 15 min at 14,000 g , and the supernatant was collected and diluted 1:1000 in LC graded H 2 O before untargeted metabolomics analysis

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Active Ingredient Per Tablet: S-Adenosylmethionine (SAMe) 90 mg L-Glutathione 10 mgInactive Ingredients: crospovidone, magnesium stearate, microcrystalline cellulose, silicon dioxide, stearic acid, Enteric Coating Ingredients Include: glycerol triacetate, hydroxypropyl methylcellulose phthalate, red #40, titanium dioxide, yellow #10

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