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It became clear that astrocytes are able to respond to neurotransmitters as manifested by changes in Ca 2+ levels

359 In a mouse model of large-scale mtDNA deletion, Pearson syndrome-like anemia worsened with the knockout of Drp1, and Drp1 knockout alone also caused anemia

Lee WC, Wen HC, Chang CP, Chen MY, Lin MT

PMID 10882107

N-acetylcysteine is an attractive compound as it is a precursor and component of the endogenous antioxidant glutathione in addition to being a free radical scavenger

The intragastric administration route used in Sun 2021 reflects the BBB-permeability and oral-bioavailability profile characterized for Dihexa in the McCoy 2013 pharmacokinetic work