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3.3 The heterozygous mutation of EpCAM aggravated the downregulation of tight junction components and pIgR in the colon of DSS-induced mice To explore the related mechanism, the expression of the components of tight junctions including members of Claudin (Cldn) family, Zo-1 and Occludin (Ocln) was first tested

10.1056/nejmc1304350 3

Studies have also examined ARA-290 in the context of metabolic stress, pain signaling, and immune cell mediated pathways, with interpretation depending on model design and exposure conditions