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Symptoms include sudden, very painful swelling of the joints, most often the base of the big toe, but can also affect the midfoot and ankle joints, knees, elbows, wrists and knuckles

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Anemia of chronic disease can be caused by the following chronic conditions: Autoimmune diseases, such as rheumatoid arthritis or lupus Cancer Infectious diseases, such as HIV/AIDS and tuberculosis Chronic kidney disease (as well as dialysis, which is used to treat it) Inflammatory bowel disease, such as Crohns disease or ulcerative colitis Other chronic diseases that involve inflammation, such as diabetes and heart failure How Is Anemia Diagnosed

This biochemical energy deficit contributes to the overwhelming sense of exhaustion experienced by patients

You might be in perimenopause, dealing with joint pain and inflammation that seemed to appear overnight, wondering why everything suddenly hurts when you haven't changed anything

PMID 8749816