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In addition to the effects of SMAD3 antagonism on MMP9, treatment with both TGF 1 and SIS3 was also able to rescue the downregulation of claudin-5 mRNA and protein (Figures 6a and b) compared with TGF 1 treatment alone

This peptide has garnered significant interest within the research community due to its remarkable stability and pleiotropic biological activities observed in a wide range of preclinical models