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Thus the reported changes in nuclear GSH induced by DEM but not by BSO are not caused by variations in the activities of these two important enzymes of glutathione metabolism

Role of metabolism in neurodegenerative disorders

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Several metal-based nanoparticles harboring multivalent elements, such as Cu 2+ /Cu + , Mn 4+/3+ /Mn 2+ , Mo 6+ /Mo 4+ , and Ir 4+ /Ir 3+ , possess strong oxidization, and can directly react with GSH (Nie et al., 2022)

The combination of NADPH and Mito-apocynin, a mitochondria-specific NADPH oxidase (NOX) inhibitor, effectively reversed KA-induced neuronal damage and the down-regulation of TP53-induced glycolysis and apoptosis regulator and NOX4 [122]

The targeted reactivation of p53 distinguishes this peptide from systemic cytotoxic strategies