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Recent studies highlight gGC as a promising agent for increasing cellular GSH levels [23], effective even when administered orally [24], with extracellular levels of 15 mol/L [25] and intracellular levels of 510 mol/L [26]

As glutamine is derived directly from the astrocytic TCA cycle (Figure 1) sufficient TCA cycle activity is also a prerequisite for sustained astrocyte glutamine synthesis (Fonnum et al