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The safety of hydrochlorothiazide and triamterene administration during pregnancy has not been established, so the combination product should be administered to pregnant women only when absolutely necessary (the potential benefits to the mother significantly outweigh the potential risk to the fetus)

Serotonin and migraine: biology and clinical implications

Side effects typically stabilize or improve

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While its gotten a lot of publicity, studies so far are limited to small groups of people

The dyschromia presents with depigmented macules, due to loss of melanocytes from the cutaneous epidermis or loss of the ability to secrete melanin