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In both, the vaccines were non-infectious, DNA-free VLPs, developed using recombinant technology, administered in conjunction with appropriate adjuvants, and three doses at 6-month intervals have been shown to elicit high-titer serum antibodies ( A study performed in young women 1525 years of age to assess the immunogenicity and efficacy of a human papillomavirus 16 and 18 (HPV-16/18) AS04-adjuvanted vaccine against cervical intraepithelial neoplasia (CIN) grade 1 or greater (CIN1+, CIN2+, or CIN3+) showed that vaccination of adolescent girls before their first sexual encounter resulted in better protection and prevention of HPV-associated cervical cancers and persistent infections ( The clinical efficacy of bivalent (HPV-16 and 18), quadrivalent (HPV- 6, 11, 16, and 18), and nonavalent (9vHPV