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We showed that RSPO2-deficient mice have reduced active -catenin signalling and a decreased mineral deposition rate and osteoblast number, similar to the phenotype observed with the knockout of LRP5/6

This was because the drug did not significantly reduce weight in 536 subjects over the course of 24 weeks 2

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ROS generation can also trigger autocatalytic reactions resulting in more free radicals that propagate the damage chain

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