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The constant production of pro-inflammatory cytokines creates a hostile cellular environment that damages the delicate inner mitochondrial membrane, specifically targeting cardiolipina unique lipid essential for anchoring the electron transport chain complexes

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TGF- primarily impacts skeletal muscle metabolism, exacerbating the occurrence of cachexia by inhibiting muscle protein synthesis and promoting muscle protein degradation

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Finally, cytochrome C expression was lower in the plaque compared to the adjacent area of the plaque (Fig