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Missing data for the trial product estimand were handled through multiple imputation using the Markov Chain Monte Carlo method, assuming that non-adherent participants would have responded similarly to adherent participants within the same treatment arm

Pickart and Margolinas 2018 review in Int J Mol Sci catalogs its regenerative and protective actions matrix remodeling, antioxidant and anti-inflammatory gene modulation, and wound-repair signaling but this is a review of largely preclinical and cell-based work (PMC6073405)

In ischemiareperfusion injury models, it preserved vascular integrity and reduced inflammation in organs such as liver, kidney, and lungslikely via endothelial stabilization through the nitric-oxide system

doi:10.1016/j.repbio.2019.07.005

3.6 Anti-CD38/ICI combination therapy is ineffective in a variety of cancer types To assess the efficacy of combining anti-CD38 and PD1/PDL1-directed ICI in more generalizable scenario, we did a comprehensive literature search and compared the objective response rate (ORR) of small scale- and clinical trial-studies that administer either a combination of anti-CD38/ICI or ICI alone in various forms of cancer ( Table 2 )

doi: 10.1002/jcp.26249