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"Conjugated Linoleic Acids impact on fat loss and lean mass." The Journal of Nutrition, 2004

Some of the earliest murine models of ECD include the leptin receptor deficient (db/db) and leptin deficient (ob/ob) mice, which exhibit polyphagia, obesity, and type 2 diabetes mellitus due to loss of leptin signaling (Tran et al., 2020)