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Xie J, Li P, Gao HF, Qian JX, Yuan LY, Wang JJ

doi: 10.1096/fj.202000201R 95 LiYLiuYLiuSGaoMWangWChenKet al

Saudi Pharm J 27(8):11461156 Swanson HI (2015) Drug metabolism by the host and gut microbiota: a partnership or rivalry

In addition, RSL3 may also serve as a chemosensitizer for cisplatin, doxorubicin, and actinomycin D by activating ferroptosis in various cancer cells, including neuroblastoma, 202 osteosarcoma, 155 lung cancer, 203 and rhabdomyosarcoma cell lines

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This metabolic bottleneck places cysteine availability at the center of cellular redox adaptation and makes it a critical determinant of GSH homeostasis under stress conditions