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doi: 10.1056/NEJM198512053132327 19 ParmianiG

Tovy et al., 2017)

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Testing b12 after 6 to 12 months of semaglutide use makes more sense than presumptive supplementation

Hence, substitution of glutamate with the longer, positively charged lysine probably causes steric hindrance that disrupts stable substrate binding and/or slows substrate release due to enhanced electrostatic interactions between the transporter and the polar side chains of porphyrin substrates