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Following Gss deficiency, the synthesis of GSH was reduced, oxidative and antioxidant was imbalanced, and autophagy was activated in the testis, all of which elevated testis ferroptosis

Park JS, Choi J, Hwang SH, Kim JK, Kim EK, Lee SY, Lee BI, Park SH, Cho ML

Miquelianin-rich lotus leaf extract (LLE) significantly increases the expression of 3-adrenergic receptor (3-AR) and p-AMP-activated protein kinase (AMPK)/AMPK ratio in the inguinal white adipose tissues of in vitro models established by the differentiation of 3T3-L1 cells and in high-fat diet-induced obese mice, thus significantly decreasing the protein expression of the mitophagy markers, PINK1, Parkin, Beclin1 and LC3B, up-regulating the expressions of p62 and Drp1, increasing the expression of beige fat-enriched marker proteins nuclear respiratory factor 1 (Nrf1), mitochondrial transcription factor A (TFAM), PPAR, and cytochrome oxidase subunit VII a (Cox7a), and upregulated the protein levels of mitochondrial biogenesis markers, silent information regulator 1 (SIRT1), peroxisome proliferator-activated receptor coactivator 1 (PGC-1), uncoupling protein 1 (UCP1) and fibroblast growth factor 21 (FGF21) levels

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Haem in macrophages is first catabolized by haem oxygenases, generating iron, carbon monoxide and biliverdin [28, 29]

Science 258, 14981501