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3 Drug repurposing 3.1 Significance of drug repurposing Drug repurposing can shorten development times by 57 years, reduce research investment costs by accounting for less than 10% of new compounds, and avoid risks such as a constant weight of generics (Turanli et al., 2021)

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103 Lysine demethylases (KDMs) and HDACs regulate tumor proliferation, cell death, and therapy resistance in GBM

Pathways that antagonize co-stimulation, including signaling downstream of the co-inhibitory receptors CTLA4 and PD-1, impair glucose uptake and metabolism

When taurine was given to mice, it protected against oxidative damage in the brain caused by cadmium and improved the antioxidant status in the animals [67]

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