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Around 23% of patients with TN do not respond to pharmacological treatment, and are considered eligible for surgery.68 In specialised units, up to 35% of patients are non-responders.69 The best time for surgical intervention is not well established, although it is reasonable to avoid excessive delay: surgery should ideally be considered after the first year of lack of response or intolerance to pharmacological treatment

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Variants in the FTO rs9939609 and MC4R rs17782313 genes influence your body's metabolic setpoint and hunger regulation

Yang AM, Lin CY, Liu SH, Syu GD, Sun HJ, Lee KC, Lin HC, Hou MC

Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression

Participants displayed slower reaction times, impaired logical reasoning, and reduced cognitive flexibility