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This conformational shift impairs the conversion of phosphoenolpyruvate (PEP), leading to the accumulation of glycolytic intermediates that fuel anabolic biosynthesis [96]

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This sophisticated crosstalk, where parallel pro-apoptotic pathways (ATF4-driven induction and CHOP-mediated fine-tuning) converge on the CHAC1 promoter, allows for precise control of cell fate under prolonged ER stress (Nomura et al., 2020)

Considering these features, AgNPs are utilized in melanoma prevention, diagnosis, and treatment, with a focus on PDT, photothermal therapy, and chemotherapy [177]