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Preclinical work has also confirmed that adeno-associated virus (AAV)-mediated delivery, such as spinal subpial delivery of AAV9, enables widespread gene silencing and can block motor neuron degeneration in rodent models of ALS (67)

[15] Additionally, the National Institute for Health and Care Excellence (NICE) produced guidance on using the RECELL System based on the consideration of evidence submitted and the views of expert advisers, and stated that the harvested skin is added to the proprietary enzyme solution in a processing unit and heated for 15 to 30 minutes to disaggregate the cells

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doi: 10.1016/j.ttbdis.2010.09.001 [DOI] [PubMed] [Google Scholar] [133].De Silva AM, Fikrig E