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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

The thiol group of cysteine is subject to reversible and irreversible post-translational thiol-modifications that lead to inactivation or activation of the transcription factor

191 Its derivatives have recently drawn attention in the field of oncology due to their antitumor potential

The most common diseases of iron overload are hereditary hemochromatosis (HH), caused by mutations in the HFE gene, and the more severe disease juvenile hemochromatosis (JH), caused by mutations in either hemojuvelin ( HJV ) [47] or hepcidin ( HAMP )

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Cell Biol Toxicol 38 , 847864 (2022)