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FIGURE 2 Succination of GPX4 Succination was discovered in 2006 as a non-enzymatic, irreversible protein modification ( Ubiquitination of GPX4 Ubiquitination is a reversible process in which the ubiquitin is added to lysine residue(s) of the substrate protein by three different types of enzymes, E1, E2, and E3

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As a damage-associated molecular pattern (DAMP), HMGB1 activates immune cells to amplify inflammation through the release of multiple cytokines or chemokines[107]

Glutathione is essential for skin health because it protects against damage caused by sunlight and other harmful influences, and helps maintain skin elasticity and a youthful appearance

Marklund, S.L., Holme, E

However, recent work on the CoQ oxidoreductase FSP1 has provided some clear indications that it is the extra-mitochondrial CoQ 10 pool at the plasma membrane that is relevant for ferroptosis protection 7,8