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Another tumor suppressor, retinoblastoma (Rb), can directly regulate the glutamine transporter ASCT2 ( SLC1A5 ) to reduce glutamine uptake via the transcription factor E2F3 (Reynolds et al., 2014)

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Therefore, we assessed whether ABCC1s role in modulating intracellular concentrations of BCL-2 inhibitors could be exploited to target Venetoclax-resistant AML

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Because inhibitors of photosynthesis have been widely used in agriculture for many years, many weed species have evolved resistance to herbicides targeting the photosynthetic electron transport chain (Gronwald Reference Gronwald, De Prado, Jorrn and Garca-Torres1997)

1), a mechanism notably distinct from the tubular recycling endosomes observed in animal and yeast cells 26,41