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Free duodenal vitamin B 12 binds to intrinsic factor (IF) [28], with the vitamin B 12 IF complex binding in a calcium-dependent manner to the cubilin receptor on enterocytes in the distal ileum, resulting in receptor-mediated endocytosis and vitamin B 12 absorption

80 A means of resolving this situation is provided by studies which have shown that malabsorption of vitamin B 12 induced by metformin can be reversed by oral supplementation of vitamin B 12, even whilst metformin treatment is continued

It has Phase 3 REDEFINE-1 data showing about 22.7% weight loss at 68 weeks, and an NDA was filed with FDA in December 2025

More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27