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Long-term human safety data beyond 12 weeks doesnt exist yet, so protocols requiring extended dosing should implement appropriate monitoring

Discussing new research with healthcare providers ensures you receive current guidance

(11) Although large doses may have side effects in some groups, generally doses up to 2,000 mcg/day are considered safe in case of deficiency

However, systemic inflammation can reduce plasma PLP levels even when a true deficiency is absent

In a clinical trial half of patients receiving a 200mg dose followed by 100mg dose 2 weeks later were experiencing a clinical response to the drug at 6 weeks, with 18% in clinical remission

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