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K.KyakulagaA.-H.MunagalaR.ParkerL.et al (2017)

Several animal studies have demonstrated that BCAAs, particularly leucine, exert significant effects on skeletal muscle protein such as stimulation of muscle protein synthesis also by possible interactions with the innate immune system with resulting modified cytokine expression [33]

Further investigation showed that exposure of RAW264.7 cells to recombinant IFN-I, including IFN- and IFN-, activated the STAT-1 signaling pathway via phosphorylation of JAK1 and tyrosine kinase 2 (TYK2)

Whether higher prevalence or different usage patterns could influence risk remains an open question, though the available data argue strongly against a direct causal effect