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Their findings open up new possibilities for the development of new GLP-1 drugs (RSC

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Clinically, an early study measuring plasma inflammatory cytokines in 23 PLWH revealed that, compared to non-depressed controls, patients with depression exhibited elevated levels of IL-15, IP-10, IL-12, and granulocyte colony-stimulating factor (G-CSF) (58)

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Notably, breast cancer cells achieve metabolic adaptation by hijacking the autophagy mechanism: under glucose-deprivation conditions, MANF-mediated mitophagy eliminates dysfunctional mitochondria through the PRKN/Parkin-dependent pathway, maintains the ATP supply and promotes tumour survival [112], suggesting that targeting the MANFPRKN interaction can break the drug resistance barrier of breast cancer under metabolic stress